Many install programs will check the version of Windows. They look for
a minimum and maximum version and will only install within that range of
versions. Often they do NOT leave the maximum open-ended because it is
unknown if their product works on as-then unknown and non-existing
versions of Windows and the vendor isn't going to expend any effort to
support their products on unsupported platforms.
You need to contact the software maker to see if their product will run
under Windows XP. If it does anything direct through DOS to manipulate
hardware, it won't work and the NT kernel bars that type of behavior.
Last I heard, Micrografx got swallowed up by Corel in 2001. They have a
KB site where you could search on "designer" to see if they mention
using it on Windows XP for whatever version of it that you have.
Alternatively, you could use VMWare Server or Virtual PC to install a
fresh copy of Windows 98 (if you did NOT upgrade from it so its license
is still valid) and run Designer from within a virtual machine that is
running Designer. If the safe mode install doesn't work as Don
suggested, and you can't get support or find an Corel article telling
you how to run the old version on Windows XP, using a virtual machine
might be the only way to get it working again by running it under
Windows 98 in a VM running on Windows XP. I had to do this for my aunt
that had some old greeting card and photo editing software.