Well of course. Either your hard drive has died, the cable is bad, the
motherboard connector is bad, power supply has failed, or a combination
of all of the foregoing.
Since you are getting the message before the operating system has loaded
- and it can't load because the drive containing it is missing - this is
hardware problem and has nothing to do with Windows.
Standard caveat: Testing hardware failures often involves swapping out
suspected parts with known-good parts. If you can't do the testing
yourself and/or are uncomfortable opening your computer, take the
machine to a professional computer repair shop (not your local
equivalent of BigComputerStore/GeekSquad).
Make sure the ribbon and power cables are plugged in tight at both ends.
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