Press DEL + ALT + CTRL to bring up the Task manager and kill the running
process for this program if it in the TSKMng then try the deletion, does it
help?.
Boot into Safe Mode and try the deletion.
You can download this tool and make the deletion when you pin point the File.
AutoRuns for Windows v8.71
By Mark Russinovich and Bryce Cogswel http://www.microsoft.com/technet/sysinternals/utilities/autoruns.mspx?wt.svl=whatsnew
Also this tool: http://www.ccleaner.com
Please read the help file before using the above tool for better result.
HTH.
nass
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