I've closely compared Vuescan's infared with Ice4 on Nikon V making
12X18 prints ...both remove literally all dust from E6, E4, C41,
neither softens grain or image at any but the "heavy" setting, which
seems never to be useful..the lightest setting is always sufficient.
Vuescan's front end makes more intuitive sense than does Nikonscan's
more attractive front end. My only beef with Vuescan is its method of
aligning frames in SA21: Nikonscan's method is usually perfect,
Vuescan's requires constant re-adjustment.
Neither Vuescan nor Nikonscan have any cropping issues with V.