Windows Defender has blocked files from starting-should I unblock them? Have no idea what they are

[bob clere]

shellopencmd:
hkcu@s-1-5-21-4243344806-1414924530-875055578-1001\software\classes\wow6432node\mailto\shell\open\command\\

shellopencmd:
hkcu@s-1-5-21-4243344806-1414924530-875055578-1001\software\classes\mailto\shell\open\command\\

file
c:\program files (x86)\microsoft office\office12\outlook.exe

Anybody know if this is legitimate?
Thanks

 

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