When in Excel, click on Tools, then Options. Select the General tab.
Towards the bottoom is an option, On Startup, Open All Files In. Get the
name of that directory. You will either have to move this file to another
location, or else delete the directory name in the textbox. You have to
decide! If there are files in this directory that you do want to open on
starting Excel, then move the Access file to another directory, otherwise
delete the name of the directory. If you need this file for Access, then
definitely move it to a suitable diretory, otherwise delete is, or preferable
move it.