I would not chance it. We've seen too many McAfee horror stories here.
If you want to be safe, download and install a more compatible
antivirus like the free Avast: http://www.avast.com/eng/avast_4_home.html
Even compatible antivirus programs will need to have their
email scanning option turned off. For more on this topic see http://www.oehelp.com/OETips.aspx#3
Ask the question on http://community.mcafee.com - if you mean VirusScan 8.5i
then ask the question in "Desktop & Server" which you will find in the
Corporate Section at the bottom of the forum.
The current home and home office products are all Vista compatible 32-bit
and shortly will be 64-bit also.
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