Hi,
I haven't tried this but:
To change the default formatting of your cell comments (so you don't have to
repeat that process each time), you need to go outside Excel and use the
Windows Display Settings dialog box. Excel uses the formatting specified for
Windows' ToolTips (the text that appear when your pointer hovers near toolbar
buttons).
You can access the Display Settings dialog box from the Control Panel. Or,
you can right-click the desktop and choose Properties. Access the Appearance
tab of the Display Properties dialog box, and select the ToolTip item. You
can then modify the font, the font size, the background color, the foreground
color, and the Bold and Italic attributes.