NO. Never compress a disk.
Never say never.
I've compressed the entire C drive on countless systems. I first did
this when a 200MB disk in a PC was hot sh*t and our developers needed
more space when the first IDE packages came into use. I don't compress
the entire disk on modern systems.
I've compresses multi-GB RAID arrays when the data we were storing was
all numeric and coming in batches of a Gig a day. Simple numeric data
compresses at 20:1. This was a production system and benchmarks showed
the the Oracle update this data went into was bottlenecked reading
uncompressed data files. Compression gave us an effective read rate
increase of 20x.
In File Explorer do a File->Open, browse to C:\ right click on it,
pick propertis/advanced and check the compress box, and pick all
subdirectories. It will pop up a message about being unable
to compress the pagefile, which you can ignore.
Do a full defrag after compressing the file system.
These days I compress the file systems that hold my Photoshop PSD
files. I get about 10% back, which is several GB.
DOn't compress anything like a database file, which gets random record
or block updates. It'll work but performance may suck, big time. If
it's read-mostly it may still be a win.