this.dataGridView1.Columns.Add("first", "first");
this.dataGridView1.Columns.Add("second", "second");
this.dataGridView1.Columns.Add("third", "third");
this.dataGridView1.Columns[0].DefaultCellStyle.ForeColor = Color.Red;
this.dataGridView1.Rows.Add(new Object[] { "first item", "second item",
"third item" });
If you've got your columns being databound, you won't manually create them
as I did, but you can still get at the first column and set the forecolor.