No, it would make a slight mockery of any security pretence don't you think.
But you can check it and tell the user to do it.
Function VBAIsTrusted() As Boolean
Dim mpVBC As Object
Dim mpAlerts As Boolean
mpAlerts = Application.DisplayAlerts
Application.DisplayAlerts = False
On Error Resume Next
Set mpVBC = ThisWorkbook.VBProject.VBComponents.Item(1)
On Error GoTo 0
Application.DisplayAlerts = mpAlerts
VBAIsTrusted = Not mpVBC Is Nothing
End Function