Using VBA, probably so, at least for most of the text in a normal presentation.
Pseudo code:
For each slide in the presentation
For each shape on the slide
If the shape has text
For each Run in the shape's text range
If the Run's text = the string you're looking for then
If the Run's font is the one you want to replace then
Change the Run's font
If none of that made any sense, then this isn't the project you want to start
learning VBA with. ;-)
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