I alway set the max size to 100 or 120.
http://support.microsoft.com/default.aspx?scid=kb;en-us;124594&Product=win2000
The profile is loaded into the registry when a user logges on. If your using
roaming profiles, they can sometimes get quite large. If the keys are not
properly deleted it can cause issues. This was a very big problem in NT 4
TS.
Keys like the HKLM\SYSTEM\CurrentControlSet\Control\Print\Printers would
just keep getting bigger.
It would take some more information to really troubleshoot this problem.
Upgrades, sidHistories, profile types etc all play a role. If this only
happens to certain users, look for corrupt or larger than normal profiles.
dw