You can setting a flag in an ApplicationState, e.g.
Application["fileAccessed"]. In Application_Start set it as false,
Application["fileAccessed"] = false;
Only when it's false to allow to access and shift it to true and also set a
flag in Session. Once finish accessing the file to shift Application flag to
false and delete Session flag. Or in Session_End to check Session flag,
accordingly shift Application flag.
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