It's information that once used is stored so that the computer doesn't have
to search for those files every time you access them, however, there is no
need to empty it. The items will repopulate the next time you run the
computer, it's the exact same number of files, no more no less before and
after emptying them and it will make no difference in the speed or
performance of your computer. Lots of debate over the Prefetch folder, but
if you try it yourself, you'll see that there is no difference, in fact the
pc may be a bit slower until those folders are populated.