With some VBA, yes.
Private Sub Workbook_Open()
ActiveWindow.Caption = ActiveWorkbook.FullName
End Sub
Private Sub Workbook_BeforeClose(Cancel As Boolean)
Application.Caption = ""
End Sub
Or selectable................
Sub CaptionToggle()
' toggles title bar between document name and full path
If ActiveWindow.Caption = ActiveWorkbook.Name Then
ActiveWindow.Caption = ActiveWorkbook.FullName
Else: ActiveWindow.Caption = ActiveWorkbook.Name
End If
End Sub
Gord Dibben MS Excel MVP