Not if you using ArcGIS which talks very nicely to Access and in fact uses
access tables as it's Geodatabase format. You point ArcGIS (from ESRI) to an
Access database and the tables light up like a xmas tree in the file open
dialogue.
However, I have found a few "I got you's".
1. No spaces in table names. ArcGIS doesn't like that at all.
2. No spaces, "(", or ")" in field names. ArcGIS doesn't like that at all
either although access doesn't mind them.
3. There are certain reserved words in ArcGIS which caused problems when
used as an Access name (i.e.. mod)
4. If you want to do a select by in ArcGIS you better have an ID field in
the Access table or ArcGIS will not even list it as selectable. (This is
what prompted the question)
I'm a meteorologist/climatologist and I find Access very useful in crunching
our data and linking that to ArcGIS is great.