Yes - a big difference. I just changed from a WD 120GB with 2MB Cache
to a Seagate 120GB with 8MB Cache and the Seagate is noticeably faster.
You cant compare them like that, you have to compare
two identical drives from the same manufacturer, one
with the 2MB cache and one with the 8MB cache.
http://www.storagereview.com/articles/200210/20021018WD2000xB_1.html
has a detailled comparison done the right way and there isnt
a lot in it with normal ops most do with desktop systems.
It is also much quieter and I think part of that is the fluid
motor but also that it can put more info into Cache.
Thats got absolutely NOTHING to do with the noise.
I used to be very aware of the WD 'crunching'
when loading apps like Outlook or IE.
Thats just head movements, and quite a bit of that is
between the area the app is being loaded from, the page
file, and the data files used, particularly with Outlook.
Presumably you also mean Outlook Express, not Outlook too.