Karen
There are 2 main locations in Vista.
C:\Windows\Temp
and
C:\Users\username\AppData\Local\Temp (Where 'username' is the name of
your account)
It is safe to delete these files and folders. If any of these files are
still 'in use' you will see a pop-up message that these files cannot be
deleted. Just click the 'Skip' button for those files.
An easier way to do this is to use the Disk Cleanup Tool.
Go to Start / All Programs / Accessories / System Tools. Click on the Disk
Cleanup item.
Click the option 'Files from all users on this computer'. In the next
window, click the drive where Vista is installed. (Usually C
.
The utility will calculate the disk space, this could take a minute or 2.
In the next window, go through the list and select all of the files you wish
to delete. Click OK.
If you need more information, click the 'How does disk cleanup work' link on
that window, or post back here.