"Hotfixes" are the updates you installed from the Windows Update
website. Do not be tempted to remove them or you will uninstall
the actual updates.
If you wish to safely remove the "uninstall files" for the
Hotfixes (i.e. $NtUninstallQxxxxxx$ files shown in Windows Explorer)
and cleanup your Add/Remove Programs list, visit MS-MVP Doug Knox's
excellent website for instructions.
Generally they are there to fix known problems, so it may not be a good idea
to delete them unless you specifically identify what they are fixing and
determine that you do not have a need for that fix.