First you have to reference the DAO or ADO library.
Current best approach is to use ADO 2.7 (if that's still
the latest version). Then I think all you can do is loop
through the range of cells and append values from
selected columns into the recordset. For example:
Dim rs As ADODB.Recordset
Dim wb As Workbook
Dim ws As Worksheet
Dim i As Long
Set rs = New ADODB.Recordset
Set wb = ThisWorkbook
Set ws = wb.ActiveSheet
rs.Fields.Append "Field1", adBSTR
rs.Fields.Append "Field2", adBSTR
rs.Open
For i = 1 To 50
rs.AddNew
rs("Field1").Value = ws.Cells(i, 1).Value
rs("Field2").Value = ws.Cells(i, 2).Value
rs.Update
Next