Many times have to reboot to run some programs

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Guest

At some point after a reboot, I will lose the ability to run certain programs, sometimes all programs. Lately, this happens Adobe reader on a daily basis at least. I think this relates to the general problem I'm having running programs, but I also have the latest version of the reader and have re-installed after uninstalling first. Windows update is automatic on my machine, so I am completely up to date with Windows also. What could this be?
 
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