I don't exactly understand what you want to do, but if you use shortcuts
you can call the EventHandler directly
I suppose that in your code you have something like :
this.menuItem.Shortcut = System.Windows.Forms.Shortcut.CtrlC;
this.menuItem.Click += new EventHandler(shortcut_Click) ;
then you can call the event handler like this: shortcut_Click(null,null)