Let me put in a belated two cents here. The question of scanning
density is almost always framed in terms of the intended output. In my
case, I do not have any immediate intended output. I simply want to
scan old negatives and slides for archival purposes. Most important, I
want to be able to crop them in the future which requires a higher
initial resolution.
I have set as my goal, obtaining digital images of the slides and
negatives which are comparable to the output of my Nikon D70. It seems
to me, that scanning at 2400 dpi with a target size equal to the
"original" document size gives me this quality resolution. Any comments?
The TIF files are about 13 MB. I could get smaller files by scanning to
JPEG. Does anyone have any thoughts about scanning at higher resolution
to a compressed JPEG file vs. scanning at a lower resolution to an
uncompressed TIF file? It seems to me that if scanning to JPEG files,
it would be could do make the files read-only to avoid degradation from
re-compressions, but I don't know of an easy way to do this.
Oh yes, I am using the Epson Perf 4870 Photo scanner.
The 2400 dpi (for 35 mm film) sounds right if the goal is to match the
image size of the D70's 3008x2000 pixel image. This uncropped size will
print 8x10 inches at 250 dpi, if that is a goal. Or it will crop a lot
and still print 6x4 inches at high quality. We should of course always
do a few and experiment, including printed tests, to refine and
understand the process and needs, before we do too much work. This will
answer the questions.
File size tradeoffs of more scan resolution vs JPG are separate issues,
not at all the same issue.
More resolution adds detail for the purpose of printing larger.
Only you can say if that is a realistic goal.
JPG files add JPG artifacts which degrade whatever size you have.
You could choose more resolution with JPG to have a similar file size,
but you must decide the appropriate image size for the goal in any case.
To be able to sit around and admire file size is not the purpose for the
image, is it?

File storage space is real cheap today. JPG is
optional, and a different issue than image size.
Modest JPG compression (a rather high JPG Quality setting) is not really
so bad, esp if the image will never be edited again, but it is always
JPG. But you said future cropping, which sounds like another save again.
Seems better to start with a TIF file if the image quality is important.
At least until all work on the image is complete. And at least for the
most important images.