John W. Vinson said:
The simplest way would be to copy and paste the table to a new table, *design
mode only*, to create a new empty table. Select this field and put a unique
Index on it (field properties in the lower left of the table design window).
Make any other desired design changes to the table at this time.
Run an Append query to migrate the data from the current table into the new
one. You'll get a warning message "x records were not added due to key
violations" - that's the dups rattling into the bit bucket.
If there are other fields in the table, it's arbitrary and unpredictable which
of the duplicates will be kept and which discarded. If that's a problem post
back with more details.