Not without some event code that would prevent the deletion after input.
Right-click on the sheet tab and "View Code".
Copy/paste the code into that module.
Alt + q to return to Excel window.
CTRL + a to select all cells.
Format>Cells>Protection........uncheck "locked"
As written, the event code will operate on any cell in columns A

to lock the
cell after data input. Options for other ranges can be provided to suit.
Private Sub Worksheet_Change(ByVal Target As Excel.Range)
On Error GoTo enditall
Application.EnableEvents = False
If Target.Cells.Column < 5 Then
ActiveSheet.Unprotect Password:="justme"
If Target.Value <> "" Then
Target.Locked = True
End If
End If
enditall:
Application.EnableEvents = True
ActiveSheet.Protect Password:="justme"
End Sub
To prevent users from seeing the code and password, protect the project from
viewing.
Alt + F11 to open Visual Basic Editor.
Select your workbook/project and right-click>VBAProject
Properties>Protection>Lock for Viewing. Apply a password and save/close the
workbook.
When re-opened, code will be unviewable or uneditable.
Gord Dibben MS Excel MVP