I have had a go at it and the first thing I noticed when online was that Firefox is no longer sluggish as I experienced it in Ubuntu 10.10. It was the speed I had always been used to. The layout on the new Mint 10 is excellent and everything worked out of the box. The updates (118 initially) went smoothly. Make sure you select the closest server to you so that you get the fast downloads as their server at this moment is very, very busy. In fact this should be always done. Here is how you get to it in Mint 10.
Menu>Admin>Update Manager>Edit>Software sources>Linux Mint Software>Download From>Other>Select Best Server>Choose Server
Once you do that you are good to go. The previous version also had this tweak and I used it then and it made a huge difference in update speeds. I also remember that I went through the routine once in a month and it used to pick a different server at times. I just thought I'd mention it here for those who are speed freaks
If you are still debating whether to install it or not here is a great
First Impressions which will give you a complete picture of what to expect from Mint 10.