Tonight I thought I'd play Fallout 3, haven't really played it yet, just installed it and went through the opening scenes.
I'd already patched the game with patch 10015 and it worked ok but after reading this thread I patched to latest version, 11035.
And blow me, after patching it wouldn't start, it hung and the sound just oscillated, in fact it hung my whole computer
So I uninstalled, reinstalled, didn't apply any patches and the game is working just fine, played about 20 minutes worth just to make sure.
I did suspect video drivers, had Nvidia V180.84 installed (Vista) and upgraded to V 181.20, latest aproved drivers. Didn't make a blind bit of difference.
So, the latest Fallout 3 patch seems to have a negative effect here.
It's late now, I worked today, I'm tired, but I'll come back to this.
Will probably play the game unpatched for now, unless I come across probs.