Disk drive error when opening links or attachments

I've just started using Windows Mail as I've just bought a new Vista
computer. Whenever I try to open an attachment or link in an email, I am
getting an error message.

"Win Mail.exe - No Disk
There is no disk in the drive. Please insert a disk into drive E:."

If I click on cancel, it comes back, and I need to repeat doing this about 5
times before it stops trying and opens up the link or attachments.

I've no idea what is causing this, or how to stop it. Can anyone help me
please>

Karen