I get this configuration error sometimes when trying to call up a
default.aspx or index.aspx homepage on my localhost IIS machine:

Description: An error occurred during the processing of a configuration
file required to service this request. Please review the specific error
details below and modify your configuration file appropriately.

Parser Error Message: It is an error to use a section registered as
allowDefinition='MachineToApplication' beyond application level. This
error can be caused by a virtual directory not being configured as an
application in IIS.

???
Muench

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Go into IIS and right click on the virtual directory where your site is and go to properties. On that first dialogue you will see a button that says Create Application. Just click that button to Create the Application. Then it should work.