Can't delete security.config.cch

Hi all,
While trying to update the "Default Profile" on a Terminal Server, I am
told that I cannot delete the old profile. This is because, even as
Administrator, I do not have access to delete the file
"security.config.cch". Here's the full path:

C:\Documents and Settings\Default User\Application Data\Microsoft\CLR
Security Config\v2.0.50727.42\security.config.cch

This is preventing me from doing "profile" updates as new software is added
and/or older version removed.

Any help would be greatly appreciated.

--
Tim.