auto respond to "reply-to"?

First off, sorry for the cross posts - they seemed appropriate.

I am attempting to set up a rule to (among other things) reply to an
email that matches certain criteria. Unfortunately the rule responds to
the email address that sent the email, rather than the "reply-to" field
- which is what I want. (even a reply to all would make me happy)

Is there a way to do this in Outlook (or any other program?)

I would prefer not to have to write my own pop3 and smtp client just to
respond to the correct emails.

Perhaps there is a way with a two-step rule? A script or other parsing
might also work.

The body of the email also contains the address i would like to respond
to - but that is not something i want to parse and code. If someone
suggests how to do it I would try it though.

thanks,
tim