Not local anesthetics specifically but yes. I am immune or allergic to almost all painkillers. When I broke my back the only painkillers they could consistently give me were paracetamol & Ibuprofen & even they have a reduced effect on me. They tried all sorts of other stuff but no go. They also used a muscle relaxant to stop my back going into spasm from the pain & that helped reduce the pain quite a bit, but nevertheless I had the hospital pain clinic all flumoxed as they tried to find something to work on me. They tell me that I'm going to have to take paracetamol & Ibuprofen for the rest of my life now... but I've already got them on the run... I'm down to 1/4 - 1/2 the daily dose of paracetamol & 2/3 the daily dose of Ibuprofen (me heap big sneaky & don't like medicines) although I still take the muscle relaxant as, if my back muscles do go into spasm, then I'm just useless.
So yes Chris, you have all my sympathy. The experience would've been awful & to have had to endure it so many times

I do hope things improve quickly